Bilateral paramedian thalamic infarction presenting with atypical pseudobulbar effect: a diagnostic challenge

  • Tahira Siddiqui Department of Medicine, Neurology Unit, Sultan Qaboos University Muscat, Oman
  • Mehwish Butt Department of Medicine, Neurology Unit, Sultan Qaboos University Muscat, Oman
  • Muhammad Imran Department of Neurology, Sultan Qaboos Comprehensive Cancer Care and Research Centre, Muscat, Oman
  • Abdullah Al-Asmi Department of Medicine, Neurology Unit, Sultan Qaboos University Muscat, Oman
  • Arunodaya R Gujjar Department of Medicine, Neurology Unit, Sultan Qaboos University Muscat, Oman
Keywords: Artery of Percheron, Thalamic stroke, Pseudobulbar effect

Abstract

Bilateral thalamic infarction is a rare subtype of ischemic stroke often resulting from occlusion of artery of Percheron (AOP), diagnosed after excluding alternative arterial, venous & non-vascular etiologies. Altered sensorium and abnormalities in eye movements are common manifestations. We present the case of a 31-year-old woman attending our tertiary care hospital with presentation of sudden onset altered mentation associated with pseudobulbar affect and dysarthria. Her neuroimaging exhibited bi-thalamic infarcts. The clinical diagnosis of this entity remains challenging, particularly when classical symptoms are lacking.

Published
2026-11-04